Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
نویسندگان
چکیده
منابع مشابه
Estimating odds ratios in genome scans: an approximate conditional likelihood approach.
In modern whole-genome scans, the use of stringent thresholds to control the genome-wide testing error distorts the estimation process, producing estimated effect sizes that may be on average far greater in magnitude than the true effect sizes. We introduce a method, based on the estimate of genetic effect and its standard error as reported by standard statistical software, to correct for this ...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2008
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2008.03.002